美通社

2024-10-29 18:00

Discovery of cancer risk associations for six novel genes

REYKJAVIK, Iceland, Oct. 29, 2024 /PRNewswire/ --Scientists at deCODE genetics/Amgen, and their collaborators have discovered six novel genes with rare germline variants that associate with cancer risk. The findings are published today in Nature Genetics under the title "Gene-based burden tests of rare germline variants identify six cancer susceptibility genes".

 
00:0000:0000:00
00:00
Kari Stefansson senior author of the paper, “Gene-based burden tests of rare germline variants identify six cancer susceptibility genes”, published today in Nature Genetics, discusses the paper with Erna V. Ivarsdottir first author on the paper.

A subset of cancers arises in individuals who are born with rare sequence variants that significantly alter their cancer risk. The discovery of such variants, like those in the BRCA1- and BRCA2 genes, has led to improved early cancer detection and the development of targeted therapies, ultimately reducing the cancer burden and improving prognosis of those carrying these mutations.

In this study, the scientists analysed three large genetic datasets from individuals of European descent, including 130,991 cancer patients and 733,486 controls. Through a gene-based burden association analysis across 22 different cancer types, they found four novel genes associated with a risk of developing cancer; the pro-apoptotic BIK for prostate cancer, the autophagy involved ATG12 for colorectal cancer, TG for thyroid cancer, and CMTR2 for both lung cancer and cutaneous melanoma. The relative increase in cancer risk conferred by these variants was substantial (90-295%), but it should be noted that the design of the study does not allow accurate assessment of absolute lifetime cancer risk.

Additionally, the researchers found the first genes with rare variants that are associated with a decreased risk of cancer. Specifically, loss of AURKB was found to protect against any cancer type, and loss of PPP1R15A was associated with 53% lower risk of breast cancer. This suggests that inhibition of PPP1R15A may be a therapeutic option for breast cancer.

The study revealed new insight into the biological mechanisms involved in cancer predisposition that will hopefully lead to better screening and treatment strategies.

Kari Stefansson CEO of deCODE genetics and senior author on the paper in Nature Genetics, with Erna V. Ivarsdottir scientists at deCODE genetics and first author.
Kari Stefansson CEO of deCODE genetics and senior author on the paper in Nature Genetics, with Erna V. Ivarsdottir scientists at deCODE genetics and first author.

 

source: deCODE genetics

想要獨家投資理財Tips?即Like etnet 全新Facebook專頁► 立即讚好

人氣文章
最近7天
1
高息定存 | 滙豐3個月港元存息高達3.8厘,6個月3.55厘
2
高息定存 | 富邦推快閃定存優惠3個月3.9厘,華僑188日3.68厘
3
專訪|林本利系列專訪逢周五登場,股市篇:勿驚美股調整,港股那些可以放心買那些勿沾手(有片)
4
專訪|林本利系列專訪一連三個周五登場,樓市篇:中原指數長線重返180,買樓勿買新樓(有片)
5
高息定存 | 6個月港元定存3.8厘新高,188日快閃優惠3.68厘
6
高息定存 | 工銀亞洲推3個月5厘息搶新客,招商永隆推快閃優惠
7
神州經脈 | 特別國債或發3萬億,滬指逼近三千四,日外相訪華
8
高息定存 | 信銀國際上調1個月定存年息至高達3.88厘
9
資源有限窒礙中小企轉型? 營商生態圈助你開拓無限商機!
10
回顧展望-新股復燃 | 政策市激發IPO 惟六成新股破發損行情
11
高息定存 | 聖誕前夕銀行加存息吸資金,大眾3個月加至3.6厘
12
回顧展望-共渡時艱 | 表列機構對今明年本港經濟增長預測
13
回顧展望-國際形勢 | 全球動盪戰火連天,特朗普時代重臨
14
回顧展望-樓盡六壬 | 甲廈租金明年料跌9%,華潤頻買民生商場
15
【FOCUS】「晶片戰」揮新大棒,技術制華恐適得其反
16
【FOCUS】「無厘頭」減息釀驚嚇,長債失控顯聯儲失信譽
17
【FOCUS】零售寒冬襲京滬港,逆市奇葩值借鏡
18
神州經脈 | 工業利潤降幅收窄,低空經濟發展司成立,滬指全周升
19
今日焦點股 | 據報螞蟻集團重組架構,劉政或出任首席財務官
20
港股 | 蕭猷華:恒指料退守至18600點,宜逢低吸納
21
內銀股 | 人行再提擇機減息降準,內銀獲中金唱好,應該點部署?
22
神州經脈 | 換手機可獲政府補貼,政策利率將降,滬指周挫逾5%
23
神州經脈 | PMI遜預期,滬指全年止跌回升,人幣年度貶幅擴
24
回顧展望-國際金融 | 金融市場現重要轉折,戰亂刺激避險
25
【FOCUS】防資本外逃+擴過境免簽,減國際收支壓力
26
回顧展望-息息相關 | 銀行股明年看好滙控,重組有利減低支出
27
新股掛牌 | 布魯可首日掛牌升41%,每手賺7395元
28
神州經脈 | 青年失業率三連降,人行約談債市激進機構,人幣續跌
29
高息定存 | 一周高息合集,銀行年尾搶資金,大眾3個月3.6厘
30
高息定存 | 一周高息合集,恒生1個月定存4厘,工銀亞洲3個月最高5厘
專業版
HV2
精裝版
SV2
串流版
IQ 登入
強化版
TQ
強化版
MQ

【etnet 30周年】多重慶祝活動一浪接一浪,好禮連環賞!

【etnet 賞你】賞 MOKO x Cheeky Cheeky「厚」有福氣利是封 及「熊 MEOW 」火柴盒造型年曆卡!

etnet榮獲HKEX Awards 2023 「最佳證券數據供應商」大獎

大國博弈

貨幣攻略

說說心理話

聖誕新年特輯

Watch Trends 2024

北上食買玩

Art Month 2024

秋天養生食療

山今養生智慧

輕鬆護老